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Biegert, C., Wagner, I., Lüdtke, R., Kotter, I., Lohmüller, C., Günaydin, I., Taxis, K. and Heide, L. (2004) Efficacy and Safety of Willow Bark Extract in the Treatment of Osteoasrthritis and Rheumatoid Arthritis: Results of 2 Randomized Double-Blind Controlled Trials. The Journal of Rheumatology, 31, 2121-2130.

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• TITLE: Effect of SRD-P401 on the Discomfort of Neck and/or Shoulder Stiffness

  AUTHORS: Akira Iizuka, Maasa Sonoda, Ruka Goto, Tokunori Matsui, Chiaki Kudoh, Katsumi Kido, Yasuhiro Komatsu

  KEYWORDS: Supplement, Anti-Inflammatory, Anti-Nociceptive, SRD-P401

  JOURNAL NAME: American Journal of Plant Sciences, Vol.8 No.5, April 26, 2017

  ABSTRACT: SRD-P401 is a newly developed healthy food supplement which has an anti-inflammatory and analgesic effect. In this report, the effects of SRD-P401 on neck and shoulder stiffness were assessed by an inquiry method in the public field. The stiffness symptoms of all participants were improved after taking SRD-P401. The symptoms of the participants who took 3 g/day and/or 9 g/day of SRD-P401 improved in a week after taking it. Unpleasant adverse effects in stomach and alimentally organs were not found during the test period. SRD-P401 showed the anti-nociceptive effect on the acetic-acid-induces abdominal writhing in rats. The potency was equivalent to aspirin. Moreover, to investigate the ability of the anti-inflammatory effects of SRD-P401, we exerted by inhibiting the Cyclooxygenase (COX) enzyme activity. SRD-P401 and its constituents inhibit the COX activity. The results of this field test indicated SRD-P401 would be a beneficial and useful healthy food supplement for a person with stiffness in neck and/or shoulder.