TITLE:
Anaerobic Biotransformation of Nitro-Compounds to Amines by Bovine Rumen Fluid
AUTHORS:
Alfonso Rodríguez, Ignacio Irazoqui, Guzmán Álvarez, Cecilia Cajarville, José Luis Repetto, Mercedes González, Hugo Cerecetto
KEYWORDS:
Biotransformation, Nitro-Compounds, Amines, Rumen, Ruminal Fluid, Bovine
JOURNAL NAME:
Green and Sustainable Chemistry,
Vol.1 No.3,
August
31,
2011
ABSTRACT: Microorganims of the bovine rumen fluid biocatalyzed the reduction of nitro-compound substrates to yield the respective amines. This enzymatic process, using ruminal contents, has rarely been reported in associa- tion with the bioreduction of nitro groups. The biotransformation reactions catalyzed by this system were de- pendent of both the electronic characteristics and the area/volume of the nitro-substrates confirming the processes are enzymatic. The semi-preparative scale biotransformation went by in good yield showing the rumen fluid may be employed in the synthesis of amines under very mild conditions and, moreover, it may have application in the bioremediation of nitro-compounds.