TITLE:
Comparative Study of Histological Alterations in Intravascular Catheter Region with and without the Use of Local Corticosteroid
AUTHORS:
Carolina Utsunomiya Muniz, Maíra Stathourakis Sampaio Amaral, Neil Ferreira Novo, Juliana Abeche Fermozelli, Willy Marcus França
KEYWORDS:
Experimental Surgery, Central Venous Catheter, Venous Thrombosis, Phlebitis, Corticosteroid
JOURNAL NAME:
Surgical Science,
Vol.8 No.4,
April
17,
2017
ABSTRACT: Introduction: Central venous access is one of the most common procedures in pediatric surgery worldwide for infusion of antibiotics, electrolytes, chemotherapy, total parenteral nutrition, etc. Local regional complications due the permanence of venous catheters are described most frequently as: thrombosis, infection, edema and local cellulites, mobilization and catheter loss. As a result, the catheter must be prematurely removed. The use of local corticosteroid (Betamethasone) can be an alternative to lengthen the catheter maintenance. Aim: This study objective is to analyze perivascular inflammatory alterations in phlebotomies with polytetrafluoroethylene (20 GA) catheter in two periods of permanence 15 and 30 days with or without local Corticosteroid. Material & Method: 32 New Zealand adult rabbits were submitted to catheterization of the External Right Jugular Vein(RJV) and were divided in 4 groups: G1: with 8 rabbits’ catheters collected in the 15th day, without corticosteroid use; G2: with 8 rabbits’ catheters collected in the 15th day, with corticosteroid use; G3: with 8 rabbits’ catheters collected in the 30th day, without corticosteroid use; G4: with 8 rabbits’ catheters collected in the 30th day, with corticosteroid use; G5: Control was the contralateral vein of the rabbit itself. Results: G2 presented lower inflammatory incidence when compared to G1, despite this difference was not statistically significant (p = 0.7333). G4 also displayed lower inflammatory incidence than G3, however it was not statistically significant (p = 0.3571). When G1 and G3 were compared with G2 and G4, there was also lower incidence of the inflammatory process in those subjects using Betamethasone, although this difference was not statistically significant (p = 0.3202). Conclusion: Betamethasone used in the vascular catheters insertion areas through phlebotomy can lessen local inflammatory manifestations of venous catheterizations.