TITLE:
Residue Study for a Standardized Macleaya cordata Extract in Growing-Finishing Swine
AUTHORS:
Lu Zhao, Ray A. Matulka, Sophie von Alvensleben, Mauro Morlacchini
KEYWORDS:
Macleaya cordata Extract, Swine, Sanguinarine, Tolerability, Residues
JOURNAL NAME:
Open Journal of Animal Sciences,
Vol.7 No.2,
April
10,
2017
ABSTRACT: The aim of this study was to assess the effects of
Sangrovit®, a standardized preparation of Macleaya cordata extract (MCE), on the
health status and retained residues in growing-finishing swine. A total of
twelve growing-finishing swine (n = 6
for each group) were randomly divided into two groups and fed either a control
feed or the control feed supplemented with 100 mg/kg Sangrovit®
(3.5 mg/kg MCE) for 28 days. The parameters for growth and health status were
evaluated during the trial and after which the animals were slaughtered.
Residual levels of MCE in swine organs and tissues were determined by measuring
sanguinarine and chelerythrine levels by LC-MS/MS. The results showed no
statistically significant differences in live weight, feed intake and average
daily gain between the treatment and control groups. The feed supplemented with
100 mg/kg Sangrovit® was well tolerated by the
swine, with no adverse effects noted during the feeding period or in the
necropsy results. Residue analysis indicated that levels of sanguinarine or
chelerythrine were under the limit of detection in all the examined tissues and
organs from the treated swine. This study demonstrates that Sangrovit®,
a standardized preparation of MCE when fed to growing-finishing swine for 28
days, at the level of 100 mg/kg in feed, does not result in sanguinarine or
chelerythrine residues in the organs or tissues.