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Shi, J., Zhang, X., Yin, L., et al. (2016) Herbal Formula GAPT Prevents Beta Amyloid Deposition Induced Ca(2+)/Calmodulin-Dependent Protein Kinase II and Ca(2+)/ Calmodulin-Dependent Protein Phosphatase 2B Imbalance in APPV717I Mice. BMC Complementary and Alternative Medicine, 16, 159.

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• TITLE: A Case of Alzheimer’s Disease Was Kept Relative Stable with Sequential Therapy for Eight Years

  AUTHORS: Mingqing Wei, Xuekai Zhang, Jing Shi, Jingnian Ni, Ting Li, Tao Lu, Yuanyuan Shi, Liping Zhang, Pengwen Wang, Shenghua Kang, Fuyun Ma, Yumeng Li, Chenmeng Li, Jinzhou Tian

  KEYWORDS: Alzheimer’s Disease, Sequential Therapy, Cholinesterase Inhibitors, Herbal Medicine

  JOURNAL NAME: World Journal of Neuroscience, Vol.7 No.2, April 7, 2017

  ABSTRACT: Background: Although Alzheimer’s disease (AD) has been intensively investigated for many years, the effective treatments are largely missing. Commonly used conventional therapy, such as cholinesterase inhibitors (ChEI) and N-methyl D-asparate receptor antagonist, have been generally considered as having symptom-relieving rather than disease-modifying effects. Thus, how to improve cognitive function beyond such effect & time limitations has become a serious challenge. Aim: In order to solve this challenge, a sequential therapy with the integration of conventional therapy and herbal therapy was applied to AD patients. Careful clinical observation was conducted in our outpatient setting. Case Presentation: A case of probable AD received the sequential therapy has achieved relative stable cognition and overall status in eight years. Conclusion: During the treatment of this AD case in eight years, sequential therapy showed great potential in stabilizing and improving cognition and overall status. Well designed preclinical and clinical studies are needed to investigate the efficacy of sequential therapy for AD and other type of dementia.