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Wade, C., Wang, L., Zhao, W.J., Cardini, F., Kronenberg, F., Gui, S.Q., Ying, Z., Zhao, N.Q., Chao, M.T. and Yu, J. (2016) Acupuncture Point Injection Treatment of Primary Dysmenorrhoea: A Randomised, Double Blind, Controlled Study. BMJ Open, 6, e008166.
https://doi.org/10.1136/bmjopen-2015-008166

has been cited by the following article:

• TITLE: Acupuncture Point Injection of Vitamin K1 to Treat Severe Primary Dysmenorrhea: Case Series at a Women’s Health Service in Bologna

  AUTHORS: Grazia Lesi, Annagiulia Gramenzi, Clarissa Frascà, Francesco Cardini, Clede Maria Garavini

  KEYWORDS: Primary Dysmenorrhea, Acupuncture, Vitamin K

  JOURNAL NAME: Chinese Medicine, Vol.8 No.1, March 31, 2017

  ABSTRACT: Introduction and Aim: Vitamin K acupuncture point injection is an effective and safe menstrual pain treatment derived from Traditional Chinese Medicine, commonly used in some Chinese hospitals. This case series investigated the effectiveness and safety of vitamin K acupuncture point injection on menstrual pain in patients with severe primary dysmenorrhea at a regional public health clinic at Bologna, Italy. Methods: From September 2006 to July 2010, 24 women were enrolled and treated during their first day of menstrual pain with an injection of 1 ml of solution containing 5 mg of vitamin K1 in an acupuncture point San Yin Jiao/Spleen 6 (SP6) bilaterally on the inside of each lower leg above the ankle. Results: Treatment was well tolerated and no major adverse events were reported. Pain relief was observed starting from 2 minutes after treatment and within 30 minutes. All treated women but one (96%) reported a substantial pain reduction (p 0.001). During the six post-treatment follow-up cycles, a trend toward a reduction of menstrual distress evaluated by the Cox Pain Intensity and Duration Scales was documented. Women reported fewer daily life restrictions and consumption of fewer analgesic tablets when compared to what they reported at the pre-treatment cycle. Conclusions: The results of this case series indicate that in primary dysmenorrhea a single vitamin K1 injection in the SP6 acupuncture point has an immediate pain-relieving effect and may ameliorate menstrual pain intensity and duration in post-treatment follow-up cycles.