TITLE:
Effects of Surgery and Palliative Chemotherapy in the Treatment of Colorectal Liver Metastasis
AUTHORS:
Nigel Bird, Ruth Bird, Ali Majeed
KEYWORDS:
Colorectal Cancer, Liver Metastasis, Surgery, Survival, Chemotherapy
JOURNAL NAME:
Surgical Science,
Vol.2 No.6,
August
16,
2011
ABSTRACT: Purpose: 1) To compare the survival of patients with colorectal liver metastases who underwent resection as the primary treatment against patients who had chemotherapy as the primary treatment. 2) To compare the survival in patients with recurrent inoperable liver metastases (after resection) treated with Oxaliplatin or Irinotecan against those patients with inoperable recurrence who were treated with 5-FU. Patients and Methods: 538 patients with colorectal liver metastases were referred to our unit between November 1997 and May 2005; 247 underwent liver resection and 291 had palliative chemotherapy. Results: Only 7.8% of non-operated patients survived for 5 years compared to 31.5% of the liver resection group. After surgery, 191 patients developed inoperable recurrent disease. These patients were treated with chemotherapy; Ox/Ir patients had a 3 year survival of 55% compared to 32% of those who received 5-FU. Our data shows that in patients who relapse after liver surgery, chemotherapy with Oxaliplatin or Irinotecan confers a significant survival benefit.