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Koptyug, I.V., Sluggett, G.W., Ghatlia, N.D., Landis, M.S., Turro, N.J., Ganapathy, S. and Bentrude, W.G. (2000) Magnetic field dependence of the 31P CIDNP in the photolysis of a benzyl phosphate. Evidence for a T--S mechanism. The Journal of Physical Chemistry, 100, 14581-14583. doi:10.1021/jp9619705

has been cited by the following article:

• TITLE: Spin effects govern DNA/RNA nucleotide polymerization

  AUTHORS: Alexander A. Tulub

  KEYWORDS: Radical Polymerization; Nucleotides

  JOURNAL NAME: Journal of Biophysical Chemistry, Vol.2 No.3, August 9, 2011

  ABSTRACT: A new radical mechanism of nucleotide polymerization is found. The finding is based on the Car-Parrinello molecular dynamics computations at 310 K with an additional spin-spin coupling term for 31P and 1H atoms and a radical pair spin term included. The mechanism is initiated by a creation of a high-energy spin-separated Mg-ATP complex in a triplet state in which the Mg prefers an uncommon chelation to the O2-O3 oxygens of the ATP. The cleavage of the complex produces the .AMP- and .O- radicals. The latter captures a proton from acidic solution (the Zundel cation) that converts it into the .OH radical. The process agrees with the protoncoupled electron transfer (PCET) mechanism. Through interacting with the HO-C3' group of the deoxyribose/ribose the .OH radical captures its hydrogen atom. The process is accompanied by producing water and the .AMP radical. The .AMP- and .AMP radicals then interact yielding a dimer. The described mechanism is easily generalized for a bigger number of adjoining nucleotides and their type. The radical mechanism is highly sensitive to the .AMP-..OH radical pair spin symmetry and the radius of the .OH diffusion. This confines the operation of the radical mechanism: it is applicable to nucleotide polymerization through the HO-C3’ group of deoxyribose/ribose (DNA/RNA polymerization) and inapplicable through the HO-C2’ group of ribose (RNA) . a result that nature has developed over evolution.