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Ellison, D.W., Onilude, O.E., Lindsey, J.C., et al. (2005) Β-Catenin Status Predicts a Favorable Outcome in Childhood MB: The United Kingdom Children’s Cancer Study Group Brain Tumor Committee. Journal of Clinical Oncology, 23, 7951-7957. https://doi.org/10.1200/JCO.2005.01.5479

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• TITLE: The Expression of PI3K, AKT, β-Catenin and VEGFR2 in Medulloblastoma

  AUTHORS: Xiao Lin, Yu Li

  KEYWORDS: PI3K, AKT, β-Catenin, VEGFR2, Medulloblastoma

  JOURNAL NAME: Journal of Biosciences and Medicines, Vol.5 No.3, March 10, 2017

  ABSTRACT: Medulloblastoma (MB) is common tumor of the central nervous system in children. It’s reported that PI3K/AKT and Wnt signal pathway have important roles in MB. This study aims to investigate the expression of PI3K, AKT, Β-catenin and VEGFR-2 in MB to find a new pathway for MB. A total of 33 MB and 17 control brain cases were retrospectively evaluate d for PI3K, AKT, β-catenin and VEGFR-2 expression by immunohistochemical staining, and the relationship with clinical feature were analyzed. The positive rate of PI3K, AKT, β-catenin and VEGFR-2 in 33 MB were significantly greater than those in control group (P