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Hartmann, W., Digon Sontgerath, B., Koch, A., et al. (2006) Phosphatidylinositol 3’-Kinase/AKT Signaling Is Activated in MB Cell Proliferation and Is Associated with Reduced Expression of PTEN. Clin Cancer Res, 12, 3019-3027. https://doi.org/10.1158/1078-0432.CCR-05-2187

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• TITLE: The Expression of PI3K, AKT, β-Catenin and VEGFR2 in Medulloblastoma

  AUTHORS: Xiao Lin, Yu Li

  KEYWORDS: PI3K, AKT, β-Catenin, VEGFR2, Medulloblastoma

  JOURNAL NAME: Journal of Biosciences and Medicines, Vol.5 No.3, March 10, 2017

  ABSTRACT: Medulloblastoma (MB) is common tumor of the central nervous system in children. It’s reported that PI3K/AKT and Wnt signal pathway have important roles in MB. This study aims to investigate the expression of PI3K, AKT, Β-catenin and VEGFR-2 in MB to find a new pathway for MB. A total of 33 MB and 17 control brain cases were retrospectively evaluate d for PI3K, AKT, β-catenin and VEGFR-2 expression by immunohistochemical staining, and the relationship with clinical feature were analyzed. The positive rate of PI3K, AKT, β-catenin and VEGFR-2 in 33 MB were significantly greater than those in control group (P