TITLE:
Construction of Enriched Resource for Primary Therapeutic Targets of Approved and Clinical Trial Drugs
AUTHORS:
Hong Yang, Chunyan Yu, Yinghong Li, Feng Zhu
KEYWORDS:
Drug, Drug Target, Indication, Protein Target of a Drug, Target of Disease
JOURNAL NAME:
Journal of Biosciences and Medicines,
Vol.5 No.3,
March
10,
2017
ABSTRACT: An assessment of the efficacy targets of drugs that represent an opportunity for targeted therapy is fundamental to the development of post-genomic research strategies within the pharmaceutical industry. Identification and validation of efficacy target is an important process in drug discovery and development. Extensive drug discovery efforts have yielded many approved and candidate drugs. Although sever drug databases provide the drug and their corresponding targets, there is an insufficient coverage of the clinical trial drugs over the past decades. Here, we conduct a comprehensive survey for current clinical trial drugs, therapeutic targets. The analysis contents include: 1) collect clinical trial drugs from different sources, 2) By analysis of the literature, we summarize the criteria for assign therapeutic targets for each drug based on its indication. The knowledge of these drugs and their targets is useful not only for drug discovery and development of targeted therapy, but also for facilitating the discovery of systems pharmacology.