TITLE:
Study of Effects of Photodynamic Therapy (PDT), in Scar-Induced Skin Wounds in Rats Wistar: The New Clinical Perspective for Ulcers
AUTHORS:
Marcus Vinicius de Mello Pinto, Aline Ronis Sampaio, Reggiani Vilela Gonçalves, Carlos Eduardo Tenório da Veiga, Lamara Laguardia Valente Rocha, Daniel Almeida da Costa, Lina Claudia Pereira Lopes, Rafael Batista Ferreira, Pamela Mara Cainelli Valim, Kellen Regina Rodrigues Chaveiro, Elias Sobreira Sathler, Richard Raphael Borges Tavares Vieira, Isabela Nardoni Bernardes
KEYWORDS:
Healing, Photodynamic Therapy (PDT), Light Emitting Diodes (LEDs), Úlcer
JOURNAL NAME:
Modern Research in Inflammation,
Vol.6 No.1,
January
28,
2017
ABSTRACT: Photodynamic therapy today is becoming an important role in the healing of lacerated tissues, since it has therapeutic resources capable of accelerating this process. One treatment option is the clinical phototherapy, and Photodynamic Therapy (PDT) is being widely used. This study aims to evaluate the effect of PDT on the healing of skin wounds in rats. We used a sample of 39 male rats Wistar divided into three groups, a control, a PDT-treated green and red with the last PDT. After 24 hours before the surgical incisions, PDT was used in both groups for 6 minutes and was evaluated in histological level, the inflammatory reaction and the repair process. The results showed that the granulation tissue was more developed in the irradiated group than in the control group and the amount of chronic inflammatory cells (monocytes, macrophages, lymphocytes and plasma cells) predominated with green phototherapy. The epithelialization in the wound margins and scarring with better quality occurred with red PDT (640 nm), which the higher deposition was of collagen. However, phototherapy not collimated of 640 nm (red) resulted in better anti-inflammatory effects. Given these answers with phototherapy not collimated green (525 nm) and red (640 nm), we conclude that the use of these wavelengths is possible with benefits, mainly with red LED.