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Dyck, P.J., Albers, J.W., Andersen, H., Arezzo, J.C., Biessels, G.J., Bril, V., Feldman, E.L., Litchy, W.J., O’Brien, P.C., Russell, J.W. and Toronto Expert Panel on Diabetic Neuropathy (2011) Diabetic Polyneuropathies: Update on Research Definition, Diagnostic Criteria and Estimation of Severity. Diabetes/Metabolism Research and Reviews, 27, 620-628.

has been cited by the following article:

• TITLE: Clinical Parameters of Metabolic Control (HbA1c) and Deterioration of Peripheral Arterial Perfusion in Type 2 Diabetes

  AUTHORS: Ma. de Lourdes Zúñiga-Martínez, Yolanda Terán-Figueroa, Laura Escarlet Guerrero-Cruz, Ángel Antonio Vértiz-Hernández

  KEYWORDS: Protein Glycation, Vascular Disease, HbA1c, Type 2 Diabetes Mellitus

  JOURNAL NAME: Journal of Diabetes Mellitus, Vol.7 No.1, February 21, 2017

  ABSTRACT: Objective: To determine the relationship between clinical parameters (HbA1c) whit metabolic control and deterioration of peripheral arterial perfusion in diabetic patients. Methodology: 108 medical records of patients with type 2 diabetes mellitus were evaluated. We obtained averages of: blood glucose (162.3 ± 73.10 mg/dl), glycated hemoglobin (HbA1c = 7.64% ± 1.77%), cholesterol (189.28 ± 35.25 mg/dl), triglycerides (189.11 ± 87.76 mg/dl), Systolic Blood Pressure (SBP = 119.69 ± 14.95 mmHg), Diastolic Blood Pressure (DBP = 77.15 ± 9.55 mmHg) and Media Blood Pressure (MBP = 91.36 ± 9.89 mmHg). We correlated variable HbA1c with vascular injury symptomatology. Results: Correlation was found between sensitivity dysfunction and HbA1c with a statistical significance of p = 0.01, and a correlation Kendal coefficient w = 0.01, any other parameter of metabolic control was not correlated with symptoms of vascular injury. Conclusion: It is remarkable that the sensitivity dysfunction is a symptom of poorly vascularized lower extremities caused for both functional impairment and structural changes in diabetic patients’ peripheral nerves, even in the preclinical stage of vascular disease. The HbA1c could also be investigated as a likely sensitivity dysfunction biomarker in DM due to the correlation presented in this study but more studies must be realized.