TITLE:
Gastric Intestinal Metaplasia Is the Most Common Histopathological Phenotype among Endoscopically Diagnosed Atrophic Gastritis Patients in North-East China
AUTHORS:
Tayyab Hamid Malik, Caihan Zhao, Jafer Mohammed AlAhmed, Sohaib Ahmad Alam, Hong Xu
KEYWORDS:
Atrophic Gastritis, Endoscopy, Metaplasia, Gastric Cancer
JOURNAL NAME:
Open Journal of Gastroenterology,
Vol.7 No.2,
February
15,
2017
ABSTRACT: Background: Gastric cancer and gastric precancerous lesions are highly prevalent in China.
However, prevalence of the different precancerous lesions has not been reported
from the north-east region of China. Detection of precancerous gastric lesions at
an early stage complemented with a follow-up strategy
for high risk groups would probably aid in declining the mortality rate in patients
with gastric cancer. Helicobacter pylori infection, salt intake, smoking, alcohol, family history of gastric cancer, atrophic
gastritis and intestinal metaplasia are established risk factors of gastric cancer.
The aim of this study was to evaluate the frequency of various
histopathological phenotypes among atrophic gastritis patients in this
region and to report if gender and increasing age carry risk in the development
of these lesions. Methods: This retrospective study was conducted on 518 patients
with endoscopic diagnosis of atrophic gastritis. Using the patient number in database,
histopathological diagnosis of the biopsy specimen of all patients was recorded.
All biopsy specimens were assessed for the presence of inflammation, atrophic gastritis,
metaplasia and/or dysplasia. Results: Intestinal metaplasia was observed in 67.38%
of patients. Dysplasia and atrophy were present in 9.46% and 3.67% patients, respectively. Gender and increasing age were not found to be risk factors for intestinal
metaplasia, dysplasia and atrophic gastritis (p-values 0.08, 0.43, 0.297 and 0.98, 0.20, 0.54;
respectively). 19.49% subjects showed inflammatory activity which was significantly
associated with female gender (P = 0.0008).
Conclusion: Intestinal metaplasia was the most histopathological
phenotype among endoscopically diagnosed atrophic gastritis patients. Large-population
based on prospective studies should be designed to determine prevalence
of precancerous lesions and the risk factors involved in the progression of these
lesions in our region.