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Xiao, B., Sanders, M.J., Underwood, E., Heath, R., Mayer, F., Carmena, D., Jing, C., Walker, P.A., Eccleston, J.F., Haire, L.F., Saiu, P., Howell, S.A., Aasland, R., Martin, S.R., Carling, D. and Gamblin, S.J. (2011) Structure of Mammalian Ampk and Its Regulation by Adp. Nature, 472, 230.
https://doi.org/10.1038/nature09932

has been cited by the following article:

• TITLE: Coumarin and Biscoumarin Inhibit in Vitro Obesity Model

  AUTHORS: Farah Mukhtar, Kimberly Stieglitz, Shamsher Ali, Asma Ejaz, Muhammad Iqbal Choudhary, Muhammad Imran Fakhri, Uzma Salar, Khalid Mohammed Khan

  KEYWORDS: Coumarin, Sulphonated Coumarin, Biscoumarin, Adipocyte Differentiation and Docking Studies

  JOURNAL NAME: Advances in Biological Chemistry, Vol.6 No.5, October 28, 2016

  ABSTRACT: Coumarin, sulphonated coumarin, and biscoumarin compounds were examined for their effects on suppressing the adipocyte differentiation in 3T3-L1 cells. Many of them inhibited the adipocyte differentiation in a dose dependent manner, amongst them compounds (7), (28), and (33) significantly suppressed the adipogenic differenti-ation, and also exhibited lipolytic effect on mature adipocytes. The active compounds potentially imitate the AMP-activated protein kinase (AMPK) ligands, there- fore, binding of these compounds with AMPK possibly shuts down the anabolic pathways. Furthermore, these compounds were docked into binding pockets with reasonable pre-dicted binding constants in the low micromolar range. These results indicate that compounds (7), (28), and (33) inhibit adipogenic development in pre- adipocytes, having lipolytic effect on mature adipocytes, and can be potent activators of human AMPK.