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Slattery, M.L., Curtin, K., Anderson, K., Ma, K.N., Ballard, L., Edwards, S., Schaffer, D., Potter, J., Leppert, M. and Samowitz, W.S. (2000) Associations between Cigarette Smoking, Lifestyle Factors, and Microsatellite Instability in Colon Tumors. Journal of the National Cancer Institute, 92, 1831-1835.
https://doi.org/10.1093/jnci/92.22.1831

has been cited by the following article:

• TITLE: No Change in Frequency of Microsatellite Instability in Colorectal Cancers over a Period of 15 or More Years

  AUTHORS: Peter Zauber, Stephen Marotta, Marlene Sabbath-Solitare

  KEYWORDS: Colorectal Cancer, Microsatellite Instability, BRAF Mutation, DNA Methylation

  JOURNAL NAME: Open Journal of Gastroenterology, Vol.7 No.2, February 8, 2017

  ABSTRACT: Microsatellite instability (MSI) is a molecular change resulting from inactivation of DNA mismatch repair systems, occurring with a reported incidence between 15% - 20% of all sporadic colorectal cancers. Our aim was to determine whether a change in the incidence of MSI in colorectal cancer had occurred at our institution over time. We assayed 106 cases from the mid-1990s and 69 cases from 15 or more years later for MSI. Those tumors with MSI were assayed for BRAF mutation and methylation. MSI was detected in 15 (14.2%) of the early cases and 11 (15.9%) of the later cases. For the two groups with MSI, a similar percentage was methylated and had a BRAF mutation. One tumor in each group was MSI, unmethylated, and BRAF wild type. Our data indicate consistency in the frequency of microsatellite unstable colorectal cancer across a time span of 15 or more years.