Article citationsMore>>

Cunningham, J.M., Kim, C.Y., Christensen, E.R., Tester, D.J., Parc, Y., Burgart, L.J., Halling, K.C., McDonnell, S.K., Schaid, D.J., Walsh Vockley, C., Kubly, V., Nelson, H., Michels, V.V. and Thibodeau, S.N. (2001) The Frequency of Hereditary Defective Mismatch Repair in Prospective Series of Unselected Colorectal Carcinomas. The American Journal of Human Genetics, 69, 780-790.
https://doi.org/10.1086/323658

has been cited by the following article:

• TITLE: No Change in Frequency of Microsatellite Instability in Colorectal Cancers over a Period of 15 or More Years

  AUTHORS: Peter Zauber, Stephen Marotta, Marlene Sabbath-Solitare

  KEYWORDS: Colorectal Cancer, Microsatellite Instability, BRAF Mutation, DNA Methylation

  JOURNAL NAME: Open Journal of Gastroenterology, Vol.7 No.2, February 8, 2017

  ABSTRACT: Microsatellite instability (MSI) is a molecular change resulting from inactivation of DNA mismatch repair systems, occurring with a reported incidence between 15% - 20% of all sporadic colorectal cancers. Our aim was to determine whether a change in the incidence of MSI in colorectal cancer had occurred at our institution over time. We assayed 106 cases from the mid-1990s and 69 cases from 15 or more years later for MSI. Those tumors with MSI were assayed for BRAF mutation and methylation. MSI was detected in 15 (14.2%) of the early cases and 11 (15.9%) of the later cases. For the two groups with MSI, a similar percentage was methylated and had a BRAF mutation. One tumor in each group was MSI, unmethylated, and BRAF wild type. Our data indicate consistency in the frequency of microsatellite unstable colorectal cancer across a time span of 15 or more years.