TITLE:
Hyperuricemia in Patients with Chronic Renal Failure in the General Hospital of National Reference of N’Djamena (Chad)
AUTHORS:
Guillaume Mahamat Abderraman, Ibrahim Hamat, Zeinabou Maiga Moussa Tondi, Ahmed Tall Lemrabott, Maria Faye, Cisse Mouhamadou Moustapha, Kossi Akomola Sabi, Ka Elhaj Fary Ka, Niang Abdou, Diouf Boucar
KEYWORDS:
Component, Formatting, Style, Styling
JOURNAL NAME:
Open Journal of Nephrology,
Vol.7 No.1,
January
24,
2017
ABSTRACT: Introduction:
Hyperuricemia is defined as a level of serum uric acid greater than or equal to
70 mg/l (420 μmol/l)
in men and
60 mg/l (360 μmol/l) in women. Several studies have shown that it is a risk
factor or a factor of progression of chronic kidney disease. Recent experimental
and epidemiological data correlate the association of hyperuricemia with
chronic kidney disease (CKD), arterial hypertension and cardiovascular
diseases, thus raising the question of the usefulness of therapeutics in the
prevention of renal diseases. The objective of this study is to seek a link
between chronic kidney disease and hyperuricemia. Materials and Methods: This
is a descriptive and analytical study conducted at hemodialysis unit and
cardiology service of General Hospital of National reference of N’Djamena
(Chad) from 1th January to 1th October 2013 (10 months).
We included all chronic kidney disease patients hospitalized in hemodialysis
unit and cardiology service who presented associated hyperuricemia. Results:
There were 712 CKD patients who were hospitalized. Among them, there were 108
patients who were included in the study and who had hyperuricemia as a
prevalence of 15.20%. The average age of patients was 35.5 years and the sex
ratio was 3/1. The age group between 40 to 60 years represented 54.6%. There
were 41.7% of traders. Hypertensive patients accounted for 49.1%; association
of diabetes and hypertension was noted in 12.90%. Renal insufficiency was
moderate in 43.5% of patients. Hyperuricemia was present in more than 90% of patients.
Profession, age, hematuria, proteinuria and hypertension were statistically positively related
to hyperuricemia. Treatment consisted of prescribing allopurinol in 84% of
patients. In more than 11% of patients the progression was unfavorable. Conclusion:
The implication of hyperuricemia in chronic kidney disease has been proved in
several recent studies. However, randomized studies at very long scales have to
be carried out to conclude from its real impact on the prevention and treatment
of chronic kidney disease.