TITLE:
Estimation of Plasma D-Dimer Levels in Sudanese Women with Preeclampsia
AUTHORS:
Sara Mohamed Nagib Abdelgadir, Nasr Eldeen Ali Mohammed Gaufri
KEYWORDS:
D-Dimer, Hypercoagulable, Preeclampsia, Sudan
JOURNAL NAME:
Open Access Library Journal,
Vol.4 No.1,
January
19,
2017
ABSTRACT: Background: The literature suggests that the haemostatic abnormalities have taken a big part in preeclampsia. D-dimer is a biomarker of fibrin formation and degradation. Objective: The present study was aimed to estimate and evaluation of the plasma D-dimer levels in Sudanese preeclampsia women. Material and Methods: This is an analytical descriptive case control study done during March 2016. A total of 100 participants were enrolled in this study, classified into two groups: the first group consisted of 50 Sudanese women diagnosed by preeclampsia as patients group, while the second group consisted of 50 normotensive women and their age matched to patients, designated as normal control group. 3 milliter of veins blood samples were collected in containers containing 3.2% tri sodium citrate as anticoagulant, then the platelet-poor plasma was prepared immediately by centrifuging for 15 minutes at approx 3000 rpm. The plasma D-dimer levels were done using MISPA-i2 (Switzerland). The data were analyzed by using SPSS (version 20). Results: The current study showed that the D-dimer level was statistically significant higher in preeclampsia women compared with normotensive pregnant women (Mean ± SD: 1.016 ± 0.158 vs 0.168 ± 0.045 with P value 0.000, respectively). Conclusion: This study concluded that the plasma D-dimer level was significantly elevated in Sudanese women with preeclampsia.