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Costantino, D. and Guaraldi, C. (2008) Effectiveness and Safety of Vaginal Suppositories for the Treatment of the Vaginal Atrophy in Postmenopausal Women: An Open, Non-Controlled Clinical Trial. European Review for Medical and Pharmacological Sciences, 12, 411-416.

has been cited by the following article:

• TITLE: Perceived Efficacy of Vaginal Dryness Relief: A Comparative Clinical Study between Sodium hyaluronate vaginal gel1 vs. Promestriene cream2

  AUTHORS: Eduardo de Oliveira Duque-Estrada, Vivian Pessoto Rosa, Mariane Martins Mosca, Heliara Lopes do Nascimento

  KEYWORDS: Vaginal Dryness, Menopause, Sodium Hyaluronate, Promestriene

  JOURNAL NAME: Advances in Sexual Medicine, Vol.7 No.1, January 18, 2017

  ABSTRACT: In the study, we report the comparative efficacy of the sodium hyaluronate gel vaginal application and promestriene cream which were tested to treat the gynecological symptoms of people who suffered from vaginal dryness. Method: 35 patients applied sodium hyaluronate vaginal gel one time a day for a period of two times a week during three weeks and other 33 patients using promestriene cream applied it every day for a period of three weeks also. Results: No significant difference was observed between vaginal application of sodium hyaluronate gel and promestriene cream, regarding both, as regarding the dryness of the intimate mucosa (p = 0.786), the attribute of moisturizing properties to the intimate mucosa (p = 0.142), the comfort sensation (p = 0.528), and no significant difference was observed regarding the fragrance of the product (p = 0.088). Conclusion: The similar results between vaginal application of both products support the use of sodium hyaluronate vaginal gel (Lubrinat®) in the initial approach of symptoms of vaginal dryness.