TITLE:
Postoperative Nausea and Vomiting Prophylaxis with Ondansetron in Diagnostic Gynecologic Laparoscopy: Preemptive versus Preventive Method
AUTHORS:
Simin Atashkhoei, Eissa Bilehjani, Solmaz Fakhari, Faraji-Azad Hanieh
KEYWORDS:
Gynecologic Laparoscopy, PONV, Ondansetron, Preemptive, Preventive
JOURNAL NAME:
Advances in Reproductive Sciences,
Vol.5 No.1,
January
13,
2017
ABSTRACT: Background and Objective: Post-operative nausea and
vomiting (PONV) is a common adverse effect
of the anesthesia in laparoscopic surgery. Ondansetron has been used for prevention and treatment of the PONV. The purpose of the present study was
to compare the effects of preemptive and preventive intravenous ondansetron on
PONV in patients undergoing diagnostic gynecologic laparoscopy. Materials & Methods: In a randomized double-blind
clinical trial, 80 women candidate of diagnostic laparoscopy, were enrolled to
study in two preemptive or preventive groups (n = 40). Ondansetron 4 mg IV was administered 5 min before anesthesia
induction or 5 min before extubation in preemptive
or preventive groups, respectively. The frequency and severity of the
PONV were compared at post-anesthetic care unit (PACU), 3th, 6th and 24th postoperatively in two groups. Also the first time of
need for the antiemetic drug was studied. Results: Demographic data were similar
but duration of anesthesia was shorter in preventive group. The PONV rate was
similar in two groups [(37.5% and 32.5% in
preemptive and preventive groups, respectively (P = 0.815)]. In preemptive group it was more intense at PACU and 24 hours
after surgery (P-value antiemetic consumption dose (P-value times were high in preemptive group (P-value = 0.001). Conclusion: Preventive ondansetron is more effective than preemptive form, in reducing the severity of PONV but not rate of the PONV in
diagnostic gynecologic laparoscopy.