TITLE:
Tocilizumab Significantly Decreases Reactive Oxygen Species Level in Patients with Rheumatoid Arthritis
AUTHORS:
Naoki Kondo, Katsumitsu Arai, Takahiro Netsu, Tomotake Kanai, Hiroshige Sano, Go Okumura, Yasufumi Kijima, Junichi Fujisawa, Naoto Endo
KEYWORDS:
Tocilizumab, Rheumatoid Arthritis, Reactive Oxygen Species, Disease Activity Score 28
JOURNAL NAME:
Open Journal of Rheumatology and Autoimmune Diseases,
Vol.7 No.1,
January
11,
2017
ABSTRACT: To determine the effect of tocilizumab (TCZ) on reactive oxygen species (ROS) in 11 patients with rheumatoid arthritis (RA), reactive oxygen metabolites (d-ROM) were measured using a Free Radical Elective Evaluator. The Disease Activity Score (DAS28) and matrix metalloproteinase-3 (MMP-3) level were also evaluated. d-ROM measured 392 ± 110 Carratelli units [U. CARR] on initiation of TCZ, and significantly decreased to 237 ± 82, 248 ± 88, and 226 ± 91 U.CARR after 3, 6, and 12 months, respectively (p