TITLE:
Bioinformatics of Profilin in Wheat
AUTHORS:
Jingming Qu, Xiaohui Zhang, Xingyue Jia, Rong Han
KEYWORDS:
Wheat, Profilin Allergic, Bioinformatics
JOURNAL NAME:
Open Journal of Immunology,
Vol.6 No.4,
December
30,
2016
ABSTRACT: Profilin is a small actin-binding protein that is essential in all organisms. While the
wheat genome sequence database is not currently available, the exploration of bioinformatics
is very important. Therefore, this article predicted the structure and function
of profilin in wheat by bioinformatics methods. The amino acid sequence of
profilin was searched in GeneBack. While its signal peptides were analyzed through
CBS prediction server, the hydrophobicities were analyzed by bioedit software, we
used EMBnet server and DNAstar to analyse the transmembrane domains and the
B-cell epitopes of the profilin respectively. Finally, the tertiary structure of the protein
was predicted through Swiss-Model. This information will help develop rational
strategies to improve the component-resolving diagnosis and immunotherapy of
profilin allergy.