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van der Dijs, F.P., Schnog, J.J., Brouwer, D.A., Velvis, H.J., van den Berg, G.A., Bakker, A.J., Duits, A.J., Muskiet, F.D. and Muskiet, F.A. (1998) Elevated Homocysteine Levels Indicate Suboptimal Folate Status in Pediatric Sickle Cell Patients. American Journal of Hematology, 59, 192-198.
https://doi.org/10.1002/(SICI)1096-8652(199811)59:3<192::AID-AJH3>3.0.CO;2-8

has been cited by the following article:

• TITLE: Significant Reduction of Vitamin B12 Levels in Sudanese Sickle Cell Disease Patients

  AUTHORS: Ishraga Ibrahim Ahmed, Areig Mohamed Sir-Elfatouh, Nasr Eldeen Ali Mohammed Gaufri

  KEYWORDS: Vitamin B12, Cobalamin, Sickle Cell Disease, Sudan

  JOURNAL NAME: Open Access Library Journal, Vol.3 No.12, December 29, 2016

  ABSTRACT: Background: Vitamin B12 (Cobalamin) one of the most important vitamins for its normal functioning to maintain the nerve system and for their role in production of DNA. Objective: This study was aimed to measure and assess the serum Cobalamin levels in Sudanese patients with Sickle-cell disease (SCD) and compared with those without Sickle-cell disease. Materials and Method: This is a case control study conducted in Sudan during March 2015. A total of 160 volunteers were enrolled in this study. 80 were known Sudanese patients professionally diagnosed with homozygous sickle cell; their age ranged from 6 months to 15 years as patients group. Further 80 normal healthy were as control group; their age and gender were similar to patient group. Serum was prepared from clotted blood samples. The Cobalamin concentrations were measured in both groups of SCD patients and in a normal healthy control group using Enzyme Linked Immune immunosorbent assay method (ELISA), Map lap Plus-Italy. For statistical analysis, the laboratory parameters were compared between the two groups and tested for statistical significance using Statistical package for social scent (SPSS) version 20. Result: In this study the mean of serum Cobalamin in the sickle cell patients was statistically significantly lower compared with the normal non-sickle cell disease group withpvalue = 0.01. Conclusion: 7.1% of Sudanese sickle cell disease has a deficient serum Cobalamin (hypocobalaminemia).