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Kondo, H., Osborne, M.L., Kolhouse, J.F., Binder, M.J., Podell, E.R., Utley, C.S., Abrams, R.S. and Allen, R.H. (1981) Nitrous Oxide Has Multiple Deleterious Effects on Cobalamin Metabolism and Causes Decreases in Activities of Both Mammalian Cobalamin-Dependent Enzymes in Rats. The Journal of Clinical Investigation, 67, 1270-1283.
https://doi.org/10.1172/JCI110155

has been cited by the following article:

• TITLE: Significant Reduction of Vitamin B12 Levels in Sudanese Sickle Cell Disease Patients

  AUTHORS: Ishraga Ibrahim Ahmed, Areig Mohamed Sir-Elfatouh, Nasr Eldeen Ali Mohammed Gaufri

  KEYWORDS: Vitamin B12, Cobalamin, Sickle Cell Disease, Sudan

  JOURNAL NAME: Open Access Library Journal, Vol.3 No.12, December 29, 2016

  ABSTRACT: Background: Vitamin B12 (Cobalamin) one of the most important vitamins for its normal functioning to maintain the nerve system and for their role in production of DNA. Objective: This study was aimed to measure and assess the serum Cobalamin levels in Sudanese patients with Sickle-cell disease (SCD) and compared with those without Sickle-cell disease. Materials and Method: This is a case control study conducted in Sudan during March 2015. A total of 160 volunteers were enrolled in this study. 80 were known Sudanese patients professionally diagnosed with homozygous sickle cell; their age ranged from 6 months to 15 years as patients group. Further 80 normal healthy were as control group; their age and gender were similar to patient group. Serum was prepared from clotted blood samples. The Cobalamin concentrations were measured in both groups of SCD patients and in a normal healthy control group using Enzyme Linked Immune immunosorbent assay method (ELISA), Map lap Plus-Italy. For statistical analysis, the laboratory parameters were compared between the two groups and tested for statistical significance using Statistical package for social scent (SPSS) version 20. Result: In this study the mean of serum Cobalamin in the sickle cell patients was statistically significantly lower compared with the normal non-sickle cell disease group withpvalue = 0.01. Conclusion: 7.1% of Sudanese sickle cell disease has a deficient serum Cobalamin (hypocobalaminemia).