Article citationsMore>>

Boadi, W.Y., Lyere, P.A. and Adunyah, S.E. (2005) In Vitro Exposure to Quercetin and Genistein Alters Lipid Peroxides and Prevents the Loss of Glutathione in Human Progenitor Mononuclar (U937) Cells. Journal of Applied Toxicology, 25, 82-88.
https://doi.org/10.1002/jat.1049

has been cited by the following article:

• TITLE: Biological Evaluation of New Schiff Bases: Synthesized from 4-Amino-3,5-dimethyl-1,2,4-triazole, Phenathroline and Bipyridine Dicarboxaldehydes

  AUTHORS: Md. Shafiqul Islam, Mohammad R. Karim, William Boadi, Seyi Falekun, Aminul H. Mirza

  KEYWORDS: [2, 2’-Bipyridine]-5, 5’-dicarboxaldehyde, Schiff Bases, Anticancer, Glutathione, Anti-Bacterial

  JOURNAL NAME: Advances in Biological Chemistry, Vol.6 No.6, December 29, 2016

  ABSTRACT: Four new Schiff bases with promising anticancer activity have been synthesized from 4-amino-3,5-dimethyl-1,2,4-triazole and di-pyridyl-aldehydes. Structures have been established by various spectroscopic methods. The compounds were tested in vitro to study their cytotoxicity and anti-oxidative activity in human lung carcinoma (A549), breast carcinoma (BT549), prostate adenocarcinoma (PC3) and mouse preadipocytes (3T3-L1) cells. Compound 1 was found to increase Glutathione (GSH) level slightly in all four cell lines. Compound 4 showed better selectivity and cytotoxicity against both BT549 and A549 cells compared to the anticancer drug tamoxifen. With the exception of compound 4 which reduced GSH levels in A549 and BT549, all other compounds maintained GSH levels in comparison to their respective controls.