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Shawali, A.S., Elghandour, A.A. and El-Sheikh, S.M. (2000) A New One-Step Synthesis of Pyrimido[1,2-b][1,2,4,5]tetrazines. Heteroatom Chemistry, 11, 87-90.

has been cited by the following article:

• TITLE: Cyclocondensation Reactions of Hydrazonoyl Chlorides with Some Azines: Synthesis of New Fused Heterocycles of Expected Microbiological Activity

  AUTHORS: Mosselhi A. M. Mohamed, Liala M. B. Abu-Alola, Ohoud N. A. Al-Zaidi, Hosam A. H. Saad

  KEYWORDS: Hydrazonoyl Chlorides, Azines, Fused Heterocycles, Biological Activity

  JOURNAL NAME: International Journal of Organic Chemistry, Vol.7 No.1, December 27, 2016

  ABSTRACT: New functionalized fused heterocycles, such as, 1,3,6,9,11-pentasubstituted-pyrido[3,2-f:6,5-f']bis([1,2,4]triazolo[4,3-a]-pyrimidin-5(1H)-ones (6) and 1,3-disubstituted-7-[(E)-2-(thiophen-2-yl)ethenyl]-1,4,9,9a-tetrahydro-6H-[1,2,4]triazino[4,3-b][1,2,4,5]-tetrazin-6-ones (16) were synthesized via reaction of the hydrazonoyl chlorides (1) with 1,3,6-triphenyl-9-thioxo-9,10-dihydro-pyrimido [4,5-b]pyrido[4,5-d][1,2,4]triazolo[4,3-a]pyrimidin-5,7(1H,8H)-di-one (5) and 4-amino-6-[(2-thiophen-2-yl)ethenyl]-3-thioxo-3,4-dihydro-[1,2,4]triazin-5(2H)-one (11), respectively. The mechanism and the regioselectivity of the studied reactions have been discussed. The biological activity of the products has been evaluated against some fungi and bacteria species. The tested compounds exhibited moderate activity against the bacteria species.