TITLE:
Cyclocondensation Reactions of Hydrazonoyl Chlorides with Some Azines: Synthesis of New Fused Heterocycles of Expected Microbiological Activity
AUTHORS:
Mosselhi A. M. Mohamed, Liala M. B. Abu-Alola, Ohoud N. A. Al-Zaidi, Hosam A. H. Saad
KEYWORDS:
Hydrazonoyl Chlorides, Azines, Fused Heterocycles, Biological Activity
JOURNAL NAME:
International Journal of Organic Chemistry,
Vol.7 No.1,
December
27,
2016
ABSTRACT: New functionalized fused heterocycles, such as, 1,3,6,9,11-pentasubstituted-pyrido[3,2-f:6,5-f']bis([1,2,4]triazolo[4,3-a]-pyrimidin-5(1H)-ones (6) and 1,3-disubstituted-7-[(E)-2-(thiophen-2-yl)ethenyl]-1,4,9,9a-tetrahydro-6H-[1,2,4]triazino[4,3-b][1,2,4,5]-tetrazin-6-ones (16) were synthesized via reaction of the hydrazonoyl chlorides (1) with
1,3,6-triphenyl-9-thioxo-9,10-dihydro-pyrimido [4,5-b]pyrido[4,5-d][1,2,4]triazolo[4,3-a]pyrimidin-5,7(1H,8H)-di-one (5) and 4-amino-6-[(2-thiophen-2-yl)ethenyl]-3-thioxo-3,4-dihydro-[1,2,4]triazin-5(2H)-one (11),
respectively. The mechanism and the regioselectivity of the studied reactions have been
discussed. The biological activity of the products has been evaluated against some fungi and bacteria
species. The tested compounds exhibited moderate activity against the bacteria
species.