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van Geest-Daalderop, J.H., Mulder, A.B., Boonman-de Winter, L.J., Hoekstra, M.M. and van den Besselaar, A.M. (2005) Preanalytical Variables and Off-Site Blood Collection: Influences on the Results of the Prothrombin Time/International Normalized Ratio Test and Implications for Monitoring of Oral Anticoagulant Therapy. Clinical Chemistry, 51, 561-568.
https://doi.org/10.1373/clinchem.2004.043174

has been cited by the following article:

• TITLE: The Effect of Time and Temperature Variables on Some Routine Coagulation Tests among Subjects of African Descent in Sokoto, North Western Nigeria

  AUTHORS: D. Ikhuenbor, F. Aghedo, I. Z. Isah, I. Iwueke, R. A. Oladigbolu, N. B. Egenti, O. Erhabor

  KEYWORDS: Effect, Time, Temperature, Coagulation, African, Sokoto, Nigeria

  JOURNAL NAME: Open Journal of Blood Diseases, Vol.6 No.4, December 26, 2016

  ABSTRACT: This study evaluated the effects of time and temperature variables on routine Pro-thrombin Time test and Activated Partial Thromboplastin Time (APTT) test among subjects of African descent in Sokoto, North Western Nigeria. Samples of 99 subjects made up of 49 male and 50 female subjects with mean age 38.3 ± 22.3 years. Coagulation tests were performed immediately specified times after phlebotomy up to 24 hours (0, 1, 2, 3, 4 and 24 hours at room temperature of 40 degrees C. Our data demonstrate that prothrombin time and APTT results are stable for up to 2 hours, remaining constant regardless of storage conditions. Post hoc tests using Bonferroni correction revealed that there were increases in PT time from 0 hour to 4 hours (17.82 ± 0.61 seconds vs 18.30 ± 0.59 seconds, respectively), from 0 hour to 24 hours (17.82 ± 0.61 seconds vs 18.48 ± 0.59 seconds, respectively), from 2 hours to 4 hours (17.89 ± 0.58 seconds vs 18.30 ± 0.59 seconds), from 2 hours to 24 hours (17.89 ± 0.58 seconds vs 18.48 ± 0.58 seconds), which were all statistically significant (p = 0.002 and p