TITLE:
Photodynamic Therapy for Medication-Related Osteonecrosis of the Jaws: A Case Report
AUTHORS:
Mônica Simões Israel, Sarah Aparecida Antero, Gisele Cuba Riche, Giulianna Lima Pinheiro, Mayara Leonel Duarte Meira, Fernanda Vieira Heimlich, Wagner Pinto das Chagas, Nathália de Almeida Freire, Maria Eliza Barbosa Ramos, Rosemiro de Menezes Maciel
KEYWORDS:
Laser, Phototherapy, Osteonecrosis, Jaws, Denosumab
JOURNAL NAME:
International Journal of Clinical Medicine,
Vol.7 No.12,
December
23,
2016
ABSTRACT: Medication-related osteonecrosis of the jaws (MRONJ) is a relatively new disease. MARX reported first cases in 2003. MRONJ relates to oral and parenteral bisphosphonates as well as to the so-called target cancer therapies but the list of medications only grows. Although MRONJ is a relatively rare condition, it can be associated to significant morbidity with feeding limitations and intense pain. More severe cases can lead to potentially life-threatening infections. Every patient initiating bisphosphonate and/or target cancer therapy must visit a dentist before starting medication because preventive measures for MRONJ are much more effective compared to surgical management of the lesions. Surgical resolution can be especially difficult to obtain in the coexistence of certain complication factors like wider bone exposures, history of nitrogen containing bisphosphonates use (mainly zolendronate) and immunodeficiency. Recently, researchers have given attention to laser therapy associated to photosensitive agents as a possible option to management of some MRONJ lesions. Our case report demonstrates the use of photodynamic therapy in a denosumab related lesion in the mandible. It seems that denosumab related lesions are more amenable to treatment and total resolution because of the marked differences between its chemical and metabolic characteristics when compared to bisphosphonates.