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Prasad, N., Labaze, G., Kopacz, J., Chwa, S., Platis, D., Pan, C.X., Russo, D., LaBombardi, V.J., Osorio, G., Pollack, S., Kreiswirth, B.N., Chen, L., Urban, C. and Segal-Maurer, S. (2016) Asymptomatic Rectal Colonization with Carbapenem-Resistant Enterobacteriaceae and Clostridium difficile among Residents of a Long-Term-Care Facility in New York City. American Journal of Infection Control, 44, 525-532.
https://doi.org/10.1016/j.ajic.2015.11.021

has been cited by the following article:

• TITLE: Detection and Characterization of β-Lactamase Encoding Genes in Carbapenem Non-Susceptible Gram-Negative Bacteria and Susceptibility of Isolates to Ceftazidime-Avibactam at a New York City Community Hospital

  AUTHORS: Carl Urban, Rita Colon-Urban, Vincent J. LaBombardi, Noriel Mariano, Nishant Prasad, Geeti Dhillon, Marina Guralnik, Sorana Segal-Maurer

  KEYWORDS: Carbapenem Non-Susceptible, Check-MDR CT103 XL Microarray, β-Lactamase Detection, Resistance Mechanisms, Ceftazidime-Avibactam

  JOURNAL NAME: Open Journal of Medical Microbiology, Vol.6 No.4, December 19, 2016

  ABSTRACT: A surveillance study was undertaken to identify prominent β-lactamase encoding genes in 131 carbapenem non-susceptible gram-negative clinical isolates at a New York City community hospital. KPC carbapenemases were detected in 89% of Enterobacteriaceae as well as additional TEM, SHV, and CTX-M class A enzymes. OXA-23 and OXA-24 were the prevalent class D carbapenemases identified in Acinetobacter species. One OXA-23 in M. morganii and one OXA-48 in K. pneumoniae were also identified. Among class C β-lactamases CMY, ACT/MIR, DHA, and FOX were detected. The in vitro activity of ceftazidime-avibactam by E-test methodology was tested with minimal inhibitory concentrations (MIC) of ≤3 μg/ml for 97.8% of all Enterobacteriaceae, MIC50/90 of 16/>256 μg/ml for carbapenem non-susceptible Acinetobacter, and 3/6 μg/ml for carbapenem non-susceptible Pseudomonas aeruginosa. Periodic surveillance of isolates to characterize current and emerging β-lactamase genotypes present in local isolates may help identify outbreak situations, provide assistance to infection control and antibiotic stewardship programs, and potentially improve patient outcomes.