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Gam, G.-T., Jeong, J.-G., Lee, N.-J., Lee, W., Ha, C.-S., Cho, W.-J. (1995) Synthesis and biological activities of copolymers of N-glycinyl maleimide with methacrylic acid and vinyl acetate. J Appl Polym Sci, 57(2), 219.

has been cited by the following article:

• TITLE: Bioengineering functional copolymers. XII. Interaction of boron-containing and PEO branched derivatives of poly(MA-alt-MVE) with HeLa cells

  AUTHORS: Mustafa Türk, Zakir M. O. Rzayev, Gülcihan Kurucu

  KEYWORDS: Synthesis; Organoboron Copolymers; Structure-Property Relations; Cytotoxicity; Antitumor Activity; Apoptotic Effect

  JOURNAL NAME: Health, Vol.2 No.1, January 15, 2010

  ABSTRACT: Novel boron-containing bioengineering copoly- mer and its α-hydoxy-ω-methoxy-poly(ethy- lene oxide (PEO) macrobranched derivatives were synthesized by (1) partially amidolysis of poly(maleic anhydride-alt-methyl vinyl ether) w?th ethanolamine ester of diphenylboronic acid and (2) esterification of synthesized B-con- taining copolymers with PEO. They had a com- bination of hydrophilic/hydrophobic linkages, free carboxylic groups, positive charges and an ionized organoboron linkage as antitumor sites, along with an ability to interact with HeLa cells. The structure, composition and properties (cy- totoxicity and antitumor activity) of synthe- sized copolymers were investigated. In vitro cytotoxicity results, obtained by the fluore scence microscopy measurements indicate that unlike the virgin copolymer, boron-containing and PEO macrobranched derivatives exhibit higher antitumor activity. It was found that organoboron copolymer exhibits the most apo- ptotic and necrotic effects against HeLa cells whereas a minor effect relative to cancer cells was observed on L929 Fibroblast cells.