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Kang, K.A., Lee, K.H., Chae, S., Zhang, R., Jung, M.S., Lee, Y., Kim, S.Y., Kim, H.S., Joo, H.G., Park, J.W., Ham, Y.M., Lee, N.H. and Hyun, J.W. (2005) Eckol Isolated from Ecklonia cava Attenuates Oxidative Stress Induced Cell Damage in Lung Fibroblast Cells. FEBS Letters, 579, 6295-6304.
https://doi.org/10.1016/j.febslet.2005.10.008

has been cited by the following article:

• TITLE: Use of a Natural Compound Made of Ecklonia bicyclis Seaweed, Tribulus terrestris and Water-Soluble Chitosan Oligosaccharide, in Male Sexual Asthenia with Mild or Mild-Moderate Erectile Dysfunction and Serum Testosterone Levels at the Lower Limit of Normal

  AUTHORS: Antonio Russo, Enrico Maisto, Leo Romis, Giuseppe Celentano

  KEYWORDS: Sexual Dysfunction, Sexual Asthenia, Testosterone, Ecklonia bicyclis Seaweed, Tribulus terrestris, Herbal Medicine

  JOURNAL NAME: Health, Vol.8 No.15, December 6, 2016

  ABSTRACT: Objectives: to evaluate the effectiveness of a natural compound made of Ecklonia bicyclis Seaweed, Tribulus terrestris and water-soluble chitosan oligosaccharide, in the male sexual asthenia with mild or mild-moderate erectile dysfunction and serum testosterone levels between 280 and 350 ng/dl. Materials and Methods: 84 male patients affected by reduced libido and serum testosterone levels at the lower limit of normal, were recruited. We have separated patients in three different age groups: group A (18 - 45 years), group B (45 - 59 years), group C (>60 years). All subjects answered the International index of erectile function questionnaire (IIEF-5) and underwent determination of serum total testosterone before and after 30 days of treatment. Results: Before treatment, the group A showed mean (± standard deviation) total testosterone 321.9 ± 19.2 ng/dl and mean IIEF-5 18.6 ± 1.97, in the group B it was 318.5 ± 18.1 ng/dl and 16.3 ± 2.66, and finally in the group C it was 305.4 ± 13.1 ng/dl and 14.2 ± 1.95 respectively. After treatment mean total testosterone and mean IIEF-5 were respectively: group A (448 ± 111.46 ng/dl and 21.84 ± 3.41); group B (453.8 ± 105.23 ng/dl and 20.4 ± 3.81); group C (385.8 ± 87.29 ng/dl and 16.7 ± 3.84). Conclusions: The treatment with Ecklonia bicyclis, Tribulus terrestris and water-soluble chitosan oligosaccharide might represent a safe and effective option on the improvement of libido and erectile function in man with testosterone level at the lower limit of normal.