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Hezova, R., Kovarikova, A., Bienertova-Vasku, J., Sachlova, M., Redova, M., Vasku, A., Svoboda, M., Radova, L., Kiss, I., Vyzula, R. and Slaby, O. (2012) Evaluation of SNPs in miR-196-a2, miR-27a and miR-146a as Risk Factors of Colorectal Cancer. World Journal of Gastroenterology, 18, 2827-2831.
https://doi.org/10.3748/wjg.v18.i22.2827

has been cited by the following article:

• TITLE: The Association between miR-196a2 rs11614913 Polymorphism and Digestive System Cancer Risk: A Meta-Analysis of 34 Studies

  AUTHORS: Rongce Zhao, Jing Zhou, Fei Liu, Yonggang Wei, Kefei Chen, Bo Li

  KEYWORDS: miR-196a2, rs11614913, Polymorphism, Digestive System Cancers, Meta-Analysis

  JOURNAL NAME: Open Journal of Internal Medicine, Vol.6 No.4, November 30, 2016

  ABSTRACT: Background: MicroRNAs (miRNAs) negatively regulate the gene expression and act as tumor suppressors or oncogenes in carcinogenesis. The association between single nucleotide polymorphism (SNP) in miR-196a2 rs11614913 and the susceptibility of digestive system cancers was inconsistent in previous studies. Methods: A standardized search of PubMed, Embase, and Cochrane library databases for publications on miR-196a2 rs11614913 polymorphism and digestive system cancer risk was performed. Then the genotype data were analyzed in a meta-analysis. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to evaluate the association. Test of heterogeneity, sensitivity analysis and assessment of publication bias were conducted in the present meta-analysis by STATA software 12.0. Results: An updated meta-analysis based on 34 independent case-control studies consisting of 13,013 cases and 16,046 controls was performed to address this association. There was a remarkable association between miR-196a2 rs11614913 polymorphism and overall digestive system cancer risk, especially in Asian populations. Moreover, subgroup analysis revealed that variant C allele increased risk of colorectal carcinoma, gastric cancer and hepatocellular carcinoma (HCC), compared with wild T allele. Conclusions: There was a remarkable association between miR-196a2 rs11614913 polymorphism and overall digestive system cancer risk, especially in Asian populations.