Article citationsMore>>

Shypshyna, M.S., Veselovsky, N.S., Myasoedov, N.F., Shram, S.I. and Fedulova, S.A. (2015) Effect of Peptide Semax on Synaptic Activity and Short-Term Plasticity of Glutamatergic Synapses of Co-Cultured Dorsal Root Ganglion and Dorsal Horn Neurons. Fiziologicheskiî Zhurnal, 61, 48-55.

has been cited by the following article:

• TITLE: Molecular Dynamics Simulation of Interaction of Short Lysine Brush and Oppositely Charged Semax Peptides

  AUTHORS: Elena Popova, Boris Okrugin, Igor Neelov

  KEYWORDS: Lysine Brush, Semax Peptides, Computer Simulation, Method of Molecular Dynamics

  JOURNAL NAME: Natural Science, Vol.8 No.12, November 29, 2016

  ABSTRACT: The possibility of complex formation by short lysine brush and therapeutic Semax peptides was investigated using molecular dynamics method. Lysine dendrimers and polymer brushes are used for drug and other (e.g., DNA, peptides, and polysaccharides) molecules delivery to different target cells. It is known that they could penetrate blood brain barrier. Since short lysine brush is nontoxic, a system containing of such brush and 8 oppositely charged Semax peptides was studied. It was obtained that stable complexes consisting of brush and peptides formed and structures of these complexes were investigated. Such complex can be used in future for delivery of Semax peptides to brain since these peptides have significant antioxidant, antihypoxic and neuroprotective effects.