TITLE:
The Activity of Serum 8-Iso-Prostaglandin F2α as Oxidative Stress Marker in Patients with Diabetes Mellitus Type 2 and Associated Dyslipidemic Hyperglycemia
AUTHORS:
Mohammed H. Mukhtar, Hoda M. El-Emshaty, Hiba S. Alamodi, Wesam A. Nasif
KEYWORDS:
Diabetes Mellitus Type 2, 8-iso-PGF2α, 8-OHdG, ELISA, Abnormal Lipid Profile
JOURNAL NAME:
Journal of Diabetes Mellitus,
Vol.6 No.4,
November
29,
2016
ABSTRACT: Background: Oxidative stress has been closely linked
to the incidence of diabetic complications. Therefore, the aim of this research
article was to study hyperglycemia and abnormal lipid profile in diabetic patient
type 2 and its correlation with oxidative stress development as measured by 8-iso-PGF2α and 8-OHdG. Methods: Fifty (50) patients
confirmed type 2 diabetes mellitus and eighty (80) non-diabetic control individuals
were included in this study. All individuals were tested for blood glucose, lipid
profile, 8-iso-PGF2α and 8-OHdG HdG. Results: The age of diabetic patients was observed to be ≥40 yrs in 96%
and diabetes was frequently detected in female than in male patients (76% vs. 24%, p ere elevated in diabetic patients compared with control
individuals (p α and 8-OHdG
were elevated significantly in diabetic
patients compared with non-diabetic control and a significant correlation was recorded
between them (r = 0.6, p α was associated with Age (r = 0.394, p α and 8-OHdG recording its role as significant predictors for the elevation
of 8-iso-PGF2α and 8-OHdG. Therefore,
hyperglycemia with oxidative stress development may play a role for dyslipidemia
and diabetic complications. Conclusion: Diabetic patient’s type 2 has a higher rate
of abnormal serum lipids and correlates significantly with lipid peroxidation and oxidized DNA bases as measured by 8-iso-PGF2α and 8-OHdG. Therefore, 8-iso-PGF2α and 8-OHdG could be used as oxidative biomarkers
for evaluating diabetic patients with early prediction of its complications and
cancer development.