TITLE:
Nonlinear Evolution Equations and Its Application to a Tumour Invasion Model
AUTHORS:
Akisato Kubo, Yuto Miyata, Hidetoshi Kobayashi, Hiroki Hoshino, Naoki Hayashi
KEYWORDS:
Nonlinear Evolution Equation, Mathematical Analysis, Tumour Invasion, Proliferation, Re-Establishment
JOURNAL NAME:
Advances in Pure Mathematics,
Vol.6 No.12,
November
17,
2016
ABSTRACT: We consider nonlinear evolution equations with logistic term satisfying initial Neumann-boundary condition and show global existence in time of solutions to the problem in arbitrary space dimension by using the method of energy. Applying the result to a mathematical model of tumour invasion, we discuss the property of the rigorous solution to the model. Finally we will show the time depending relationship and interaction between tumour cells, the surrounding tissue and matrix degradation enzymes in the model by computer simulations. It is seen that our mathematical result of the existence and asymptotic behaviour of solutions verifies our simulations, which also confirm the mathematical result visibly.