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Hofman, A., Ott, A., Breteler M.M., Bots, M.L., Slooter, A.J., van Harskamp, F., van Dujin, C.N., van Broeckhoven, C. and Grobbee, D.E. (1997) Artherosclerosis, Apolipoprotein E, and the Prevalence of Dementia and Alzheimer’s Disease in the Rotterdam Study. The Lancet, 349, 151-154.
http://dx.doi.org/10.1016/S0140-6736(96)09328-2

has been cited by the following article:

• TITLE: Homocysteine and Cognitive Impairment in Thai Elderly

  AUTHORS: Duangkamol Viroonudomphol, Saowanee Kajanachumpol, Chaiwat Prawettongsopon

  KEYWORDS: Homocysteine, Cognitive Impairment, Thai

  JOURNAL NAME: World Journal of Engineering and Technology, Vol.4 No.4, November 9, 2016

  ABSTRACT: Background: The prevalence and incidence of dementia increase dramatically with age. Cognitive impairment is one major symptom of dementia. Older persons increase in our society, which means a big number of people with decreased cognitive function. So it is important to find out risk factors. The amino acid homocysteine may be a risk factor. Objective: The aim was to determine the independent association of homocysteine and cognitive performance in Thai elderly. Design: Concentrations of homocysteine were measured in fasting blood samples of 100 Thais aged 60 - 80 years. Global cognitive function was assessed by using with mini-Mental State Examination score (MMSE), and cognitive functions were assessed by a neuropsychological test battery. The relationship between homocysteine levels and neuropsychological test scores was assessed by multiple linear regression. Results: In the crude model, homocysteine was inversely associated with scores for learning slope test (B = ?0.048, p = 0.042) and verbal pair total test (B = ?0.124, p = 0.032). After adjusting for confounders, no association was found between homocysteine and cognitive impairment. Age (B = ?0.129, p = 0.007) was found to be a significant determinant of decreased learning slope score. Similarly, age (B = ?0.298, p = 0.009) and education (B = 0.267, p = 0.029) were found to be significant determinants of decreased verbal pair total score. Conclusions: In this study, it was found that no association between homocysteine and cognitive impairment in a population of institutionalized subjects. Age and education were more significantly associated with cognitive impairment scores than homocysteine.