TITLE:
HPV Related Retroperitoneal Squamous Cell Cancer: A Rare Presentation
AUTHORS:
Anita Agrawal, Rajni Chibbar, Anahita Safavi-Naini
KEYWORDS:
Primary Retroperitoneal Squamous Cell Carcinoma, HPV Infection, Cervical Neoplasia
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.7 No.12,
November
9,
2016
ABSTRACT: Objective:
To describe the primary carcinoma of the retroperitoneum that was positive for
human papillomavirus (HPV), a surrogate molecular marker for high-risk HPV
(p16) and p53. Methods: This is a case report. Results: We report a case of 50-year-old woman
with a large retroperitoneal mass (squamous cell carcinoma on histology) that was
treated in September of 2014 with radical concurrent chemotherapy with weekly
cisplatin and pelvic radiation (4500 cGY) and additional right pelvic boost of
900 cGY. It was assumed she had FIGO
stage IIIB local advanced cervical cancer. She initially presented with the
right leg swelling, severe pain and difficulty in walking and was treated with
antibiotics for presumed cellulitis. Several months later right leg extensive
deep vein thrombosis (DVT) was diagnosed and was started on anticoagulation. CT
scan and MRI reported a large right-sided retroperitoneal mass occluding the
illiac vessels and ureter. The mass had invaded into the adjacent pelvic
sidewall, with destruction of the iliacus muscle and underlying iliac wing. MRI
showed that the cervix and uterus were both normal. On examination cervix
appeared grossly normal and cervical punch biopsy revealed HSIL only. CT-guided
biopsy of the mass revealed a moderately differentiated squamous cell carcinoma
positive for p16 and p53. Conclusion: Primary squamous
cell carcinoma of the retroperitoneum is a real entity that is
unknown. It is unclear if primary neoplasia in the cervix was small from which
a cell clone arose and migrated to the retroperitoneal space.