TITLE:
Laxative Effect of Some Plants Extracts Used in Traditional Pharmacopoeia on the Intestine of Rabbit
AUTHORS:
Imar Djibrine Soudy, Arada Izzedine Abdelaziz, Djidda Alhadj, Ousmane Dahab Atteib, Boukar Abba Alifa, Djimalbaye Mandiguel, Ngomde Djasnabaye, Hassane Mahamat Hassane
KEYWORDS:
Constipation, Intestinal Contraction, Rabbit, Adansonia digitata, Psidium guayava, Ziziphus mauritiana
JOURNAL NAME:
Food and Nutrition Sciences,
Vol.7 No.12,
October
27,
2016
ABSTRACT: Constipation is a condition in which a person or animal has difficulty in eliminating
solid waste from the body and the faeces are hard and dry. It is mainly characterized
by a difficulty in defecation. The aim of the study is to assess the laxative effect of
some plants such as Adansonia digitata , Ziziphus mauritiana and Psidium guayava traditionally used in Chad to treat the problems of constipation. The Microdynamometer
method (Biomecatronics) is used to carry out this study. The outcomes show
that the extracts’ leaves of Psidium guayava and barks of Ziziphus mauritiana did not
lead a significant contraction of duodenum of rabbit until a maximum concentration
of 1000 μg, but the extracts’ leaves of Adansonia digitata had a significant effect (P Adansonia digitata varies with the increase of its concentration (dose dependent) with a maximum
of 500 μg and the minimal effect is inferior to 10 μg. On the other hand, the extract
of Adansonia digitata has a musculotrope effect because the results have shown that
inhibitive molecules such as the atropine and the naloxone do not have to inhibit the
action of Adansonia digitata on the intestinal motility of rabbit. Thus, the extract of
this plant would reduce significantly the time of intestinal transit and it will be an
important laxative drug candidate as described traditionally in Chad.