TITLE:
The Human Microbiome and I-Cubed: A Modern Medical Paradigm
AUTHORS:
David S. Younger
KEYWORDS:
I-Cubed (Infection, Immunity, Inflammation), Microbiome, Neuroepidemiology
JOURNAL NAME:
World Journal of Neuroscience,
Vol.6 No.4,
October
27,
2016
ABSTRACT: Background:
Over the past decade, there has been recognition of the importance of the human
microbiome. Beyond improved microbial cataloguing through high- throughput genetic
sequencing, we have learned that
human beings are superorganisms
integrating the identity, function and immunity of resident bacterial, while
prepared throughout own innate and adaptive immune systems, to deal with
invading organisms. Hypothesis: In keeping with the dynamic relation of
infection, immunity and inflammation contained in I-Cubed, illness arises when
protective immunity becomes the source of autoimmunity, conditioned by
environmental and genetic factors. Results: This paradigm explains the
etiopathogenesis of diverse medical (type 1 diabetes, spondyloarthropathy),
neurologic (Lyme neuroborreliosis), and neuropsychiatric disorders (PANDAS, and
autism spectrum disorders). Conclusion: Successful treatments employing
immune-modulatory therapy may be employed. Public health officials will be
called upon to guide the public’s understanding and mitigate the risk of disorders
that result from the interplay of the human microbiome and I-Cubed.