TITLE:
Hypofractionated Radiation Therapy for the Treatment of Breast Cancer: Experience of National Institute of Oncology, Rabat, Morocco
AUTHORS:
A. S. Koné, A. Diakité, S. Ahid, I. M. Diarra, K. Diabaté, R. Abouqal, Y. Cherrah, N. Benjaafar
KEYWORDS:
Hypofractionated Radiation Therapy, Breast Cancer, Local Control, Tolerance
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.7 No.10,
October
27,
2016
ABSTRACT: Hypofractionated radiation
therapy has proven effective on locoregional control and tolerance in the
adjuvant treatment of breast cancer. The aim of this study is to compare the
results of hypofractionated radiation therapy versus conventional radiation
therapy in terms of local control and tolerance. It was a retrospective study
of patients
observations collected from January
2007 to December 2008 in Department
of Radiation Therapy in
Institut National d’Oncologie de Rabat. The
treatment results were evaluated by the rate of locoregional recurrence,
distant recurrence and research of late toxicities. Radiotherapy
was delivered using the same technique in both groups, by gamma photons of
cobalt 60 with an energy of 1.25 MeV. They were
2 groups: the first group treated with standard dose rate and the second group
treated by hypofractionated radiation therapy.
The mean age of the patients was 42.8 ± 6.9 years
old in the standard group and 43.22 ± 7.2 years
old in the hypofractionation group. We noted a predominance of infiltrating
ductal carcinoma. The majority of patients were pT2, pN0 and pN1. The majority of patients had radical surgery and
chemotherapy with anthracyclines in both groups. We noted a
statistically significant difference in the irradiation of chest wall between
the standard (89.2%) and hypofractionated group (70.3%), with p = 0.043. The
median duration of radiation therapy was statistically different in both
groups: 39 days in the standard and 23 days in the hypofractionated group (p 0.001).
The local recurrences were statistically identical to 12 and 24 months (p = 0.999).
Concerning toxicities, the frequency of adverse event was similar in both
groups. Hypofractionated
radiation therapy with a total dose of 42 Gy at 2.8 Gy per fraction in 5
fractions weekly is comparable to standard radiotherapy in terms of local
control and tolerance and is therefore a very good alternative to standard
treatment.