TITLE:
A Diet with 3% of Energy from a Mixture of Omega-3 Fatty Acids Significantly Increases in Vivo Lipid Peroxidation in Postmenopausal Women
AUTHORS:
A. Saari Csallany, Cheryl E. Ainslie-Waldman, Lindsay R. Young, Chi Chen, Mindy S. Kurzer, Susan K. Raatz
KEYWORDS:
Lipid Peroxidation, n – 3 Fatty Acids, Human, HHE, 4-Hydroxyhexenal, HDE, 4-Hydroxydecenal, α, β-4-Hydroxyaldehydes, HPLC, MS
JOURNAL NAME:
Food and Nutrition Sciences,
Vol.7 No.12,
October
20,
2016
ABSTRACT: Dietary omega-3 (n - 3) polyunsaturated fatty acids (PUFA) are recommended by
public health organizations to reduce the risk of cardiovascular disease, and several
epidemiological studies have suggested there is an inverse association between n - 3
intake and human cancers. However, n - 3 are susceptible to an increase in lipid peroxidation
in the human body. As part of a crossover dietary intervention study of a
diet (20% of energy from fat) with or without an additional 3% of energy from a
mixture of n - 3 (with 5.36 g α-linolenic acid and 1.45 g eicosapentaenoic acid and
docosahexaenoic acid per 2000 kcal per day), we measured total in vivo lipid peroxidation
in healthy postmenopausal women (n = 15). Our results indicated that the diet
with 3% of energy from n - 3 significantly increased the urinary concentrations of
total polar lipophilic aldehydes and related compounds produced via lipid peroxidation
(p α, β-unsaturated hydroxy aldehydes 4-hydroxy-2-trans -
hexenal (p trans -decenal (p trans -decenal in the urine of individuals consuming n - 3.
These results demonstrate that an increase in 3% of energy from dietary n – 3 increases in vivo lipid peroxidation.