TITLE:
Amyloïdosis Complicating Behcet’s Disease
AUTHORS:
Amel Harzallah, Hayet Kaaroud El Jery, Mariem Hajji, Ikram Mami, Rim Goucha, Sami Turki, Fethi Ben Hamida, Madiha Mahfoudhi, Taieb Ben Abdallah
KEYWORDS:
Amyloidosis, Prognosis, Behcet’s Disease
JOURNAL NAME:
Open Journal of Clinical Diagnostics,
Vol.6 No.3,
September
27,
2016
ABSTRACT: Background: Behcet’s disease is
a vasculitis affecting several organs. A renal involvement is rarely described.
It is most of the time about a renal amyloidosis. Patients and methods: It is a
descriptive retrospective study concerning the patients followed in our department
for a Behcet’s disease having presented a renal amyloidosis. Results: It is about 4 men with average age of 38.25 years old. The renal
involvement was revealed after an average delay of 5.7 years by a nephrotic
syndrome in all cases. A renal insufficiency was noted in 3 cases with an
average serum creatinine of 587 μmol/l (127 - 1490). The type of the
amyloidosis was AA in 2 cases. The treatment contained colchicines in every
case. The evolution was marked by the worsening of the renal function leading
to end stage renal disease in 3 cases. Death occurred in 1 case and one patient
lost to follow up. Discussion: Renal amyloidosis can complicate the evolution
of a Behcet’s disease. It occurs generally 1 to 10 years after the beginning of
the disease. Once installed, it evolves generally towards the chronic renal
insufficiency and can condition the forecast of this affection. Conclusion: Amyloidosis
is a rare complication of the Behcet’s disease. Its screening is so desirable
to improve the renal prognosis of these patients.