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Toyokini, T., Walsh, J.C., Domingez, A., Phelps, M.E., Barrio, J.R., Gambhir, S.S. and Satyamurty, N. (2003) Synthesis of a New Heterobi-functional Linker, N-[4-(aminooxy) butyl]maleimide, for Facile Access to a Thiol-Reactive 18F-Labeling Agent. Bioconjugate Chemistry, 14, 1253-1259.
http://dx.doi.org/10.1021/bc034107y

has been cited by the following article:

• TITLE: Semi-Automated Synthesis of [F-18]FBAM, a Thiol Reactive Prosthetic Group, Using Continuous Flow Chemistry

  AUTHORS: Murthy R. Akula, Srinivasa R. Marepally, Lee T. Collier, W. George Kabalka

  KEYWORDS: Bifunctional Agent, Micro-Reactor, 6-Bromohexnol, Radiofluorination, Appel Reaction

  JOURNAL NAME: International Journal of Organic Chemistry, Vol.6 No.3, September 26, 2016

  ABSTRACT: [F-18]FBAM, a thiol reactive bifunctional agent, was successfully synthesized using continuous flow chemistry in a micro reactor that is part of Advion NanoTek Micro-fluidic Synthesizer. As the radiofluorination was carried out microfluidically, a very small amount of precursor was used and over all radiochemical yield was 38% ± 4% (n = 8, decay corrected) and the radiochemical purity was ≥98% with specific activity of 430 mC/μmol. The total reaction time including HPLC purification was 55 min that is 14 min more than manual synthesis and 6 min less than fully automated synthesis.