TITLE:
Severity of Chronic Obstructive Pulmonary Disease and the Prognosis of Non-Small Cell Lung Cancer Patients
AUTHORS:
Masaki Tomita, Takanori Ayabe, Eiichi Chosa, Naohiro Nose, Kazuyo Tsuchiya, Kunihide Nakamura
KEYWORDS:
Non-Small Cell Lung Cancer, COPD, GOLD, Prognosis
JOURNAL NAME:
Advances in Lung Cancer,
Vol.5 No.2,
June
20,
2016
ABSTRACT: Objectives: We retrospectively analyzed whether the severity of
Chronic Obstructive Pulmonary Disease (COPD) affected disease-specific survival in Non-Small-Cell Lung
Cancer (NSCLC) patients after surgical resection. Methods: We enrolled 210 NSCLC patients who underwent curative surgery
between 2009 and 2011. Classification of COPD severity was based on guidelines
of the Global Initiative for Chronic Obstructive Lung Disease (GOLD). Results: A total of 55 patients were diagnosed with COPD. The 5-year disease-specific survival of patients with COPD was not different
compared with that of patients without COPD. Among the COPD patients, 40 were
classified as GOLD 1, 13 as GOLD 2, and 2 as GOLD 3. Although the number of patients
with GOLD 2 - 3 was small, the 5-year disease-specific survival of patients with GOLD 2 - 3 was
significantly poorer. We found the prognostic significance of GOLD 2 - 3 in
univariate analysis, but
failed to find this in multivariate analysis. Conclusions: There is a possibility that the severity of COPD
might be useful to predict the prognosis of NSCLC patients. Further studies with large study population are
needed.