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Pratt, J.P., Ravnic, D.J., Huss, H.T., Jiang, X., Orozco, B.S., Mentzer, S.J. (2005) Melittin-induced membrane permeability: a nonosmotic mechanism of cell death. In Vitro Cellular & Developmental Biology. Animal, 41, 349-355.

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• TITLE: Low molecular fucoidan and its macromolecular complex with bee venom melittin

  AUTHORS: G. T. Mavlonov, J. M Lee, Lee Shin, T. H. Yi, I. Y. Abdurakhmonov

  KEYWORDS: Fucoidan; Free Radical Depolymerization; Melittin; Anti-Inflammatory Activity

  JOURNAL NAME: Advances in Bioscience and Biotechnology, Vol.2 No.4, August 16, 2011

  ABSTRACT: Low molecular weight (LMW) fucoidan, obtained by free radical depolymerization of high molecular polysaccharide extract of brown algae Hizikia fusiformis, was complexed with HPLC purified bee venom melittin. Water soluble form of the LMW fucoidan – melittin complex shows increased anti-inflammatory activity, inhibiting the production of nitric oxide in murine macrophage cell line Raw 264.7. The LMW fucoidan:melitin complex obtained in this study showed good biological activities, resulting in 2-fold reduction of the melittin toxicity. The fucoidan: melittin macromolecular complex obtained should be useful in future therapeutic applications.