TITLE:
Broad-Spectrum Antibacterial Characteristics of Four Novel Borate-Based Bioactive Glasses
AUTHORS:
Megan Ottomeyer, Ali Mohammadkah, Delbert Day, David Westenberg
KEYWORDS:
Bioactive Glass, Antibacterial Properties, Metal Ions
JOURNAL NAME:
Advances in Microbiology,
Vol.6 No.10,
September
6,
2016
ABSTRACT: Bioactive glasses have been developed for medical
applications in the body for bone and tissue repair and regeneration. We have
developed a borate-containing bioactive glass (13-93B3, referred to as B3), which
is undergoing clinical trials to assess its wound-healing properties. To
complement the healing properties of B3, metal ion dopants have been added to enhance
its antimicrobial properties. Bioactive glasses doped with silver, gallium or
iodine ions were found to have broad spectrum antimicrobial effects on
clinically relevant bacteria including MRSA. While the B3 glass alone was
sufficient to produce antibacterial effects on select bacteria, adding dopants
enhanced the broad-spectrum antibacterial properties: Live-Dead staining
fluorescence microscopy suggests cell membrane integrity is disrupted in gram
positive bacteria exposed to the glass compounds, but not gram negative
bacteria, indicating multiple mechanisms of action for each glass formulation.