TITLE:
Evaluation of Circulating Fatty Acid Synthase as a Biomarker in Non-Alcoholic Fatty Liver Disease
AUTHORS:
Aida Abdeen Mahmoud, Asmaa N. Mohammad, Mohamed Abdel Wahab Ezat
KEYWORDS:
NAFLD, Fatty Acid Synthase, Free Fatty Acids
JOURNAL NAME:
Open Journal of Gastroenterology,
Vol.6 No.9,
August
30,
2016
ABSTRACT: Background: The liver is the corner stone in lipid metabolism, free fatty acid uptake, synthesizing, storing and exporting lipids; non-alcoholic fatty liver disease (NAFLD) develops if there is any interruption or derangements in lipid metabolim. Fatty acid synthase (FAS) is the major enzyme in lipogenesis, and its circulating level is a bi-omarker of metabolically demanding human diseases. Aim of the Work: To evaluate the level of circulating FAS in NAFLD patients and to correlate it to serum lipid pa-rameters. Materials and Methods: The study included forty NAFLD patients and forty age and sex-matched healthy subjects as controls. Results: FAS levels were signifi-cantly higher in NAFLD patients compared to their level in the controls (P