TITLE:
The Effect of High Carbohydrate Consumption on Glucose Levels and Antibody Production in Nonobese Diabetic Mice
AUTHORS:
Tonicley Alexandre da Silva, Caio José de Carvalho-Filho, Elizabeth de Sousa Barcelos Barroqueiro, Deysianne Costa das Chagas, Flá via Raquel Fernandes Nascimento, Rosane Nassar Meireles Guerra
KEYWORDS:
Carbohydrates, Diabetes, Flour, NOD, Mice, Diet
JOURNAL NAME:
Food and Nutrition Sciences,
Vol.7 No.10,
August
29,
2016
ABSTRACT: The aim
of this study was to evaluate the effect of chronic treatment with diets rich
in carbohydrates on the IgM and IgG antibody production and the seric glucose
concentration in diabetes. Nonobese diabetic (NOD) mice received, ad libitum, by oral route, the diet consisting of an aqueous extract (20
mg/mL) of the following flours: babassu mesocarp, manioc, corn or rice, during
120 days. The diet intake was monitored throughout this period. At the end, the
weight variation, blood glucose, serum IgG and IgM antibody and IgM
anti-insulin titers, were determined. The babassu and manioc flour extracts
altered Purina chow intake and these animals also presented a significant
increase in body weight. In contrast, treatment with rice flour resulted in a
significant weight loss. Moderate to severe hyperglycemia was observed in the
groups receiving rice and manioc, whereas treatment with babassu mesocarp flour
and cornmeal resulted in hypoglycemia. The extracts did not alter the IgG
concentration. On the other hand, the cornmeal extract caused a marked reduction
in both total IgM and anti-insulin IgM antibody production. Although babassu
mesocarp flour, cornmeal and manioc flour caused important variations in the
parameters studied, only treatment with the rice flour extract anticipated the
onset of diabetes in male mice genetically predisposed to the disease.